Construction of hypervesiculationEscherichia colistrains and application for secretory protein production
Abstract
Outer membrane vesicles (OMVs) are extracellular vesicles released from the surface of Gram-negative bacteria, including Escherichia coli. Several gene-deficient mutants relating to envelope stress (nlpI and degP) and phospholipid accumulation in the outer leaflet of the outer membrane (mlaA and mlaE) increase OMV production. This study examined the combinatorial deletion of these genes in E. coli and its effect on OMV production. The nlpI and...
Paper Details
Title
Construction of hypervesiculationEscherichia colistrains and application for secretory protein production
Published Date
Dec 13, 2019
Volume
117
Issue
3
Pages
701 - 709
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