A framework for modeling radiation induced lymphopenia in radiotherapy
Abstract
Introduction Associations between radiation-induced lymphopenia (RIL) and survival have been extensively reported. However, the immune system is not considered as an organ-at-risk (OAR) in radiotherapy. This study aimed to develop the framework of an immune OAR model that may be utilized to predict and minimize RIL. Methods A dynamic model was first developed for lymphocyte trafficking among 5 compartments of the immune system. Radiation dose to...
Paper Details
Title
A framework for modeling radiation induced lymphopenia in radiotherapy
Published Date
Mar 1, 2020
Journal
Volume
144
Pages
105 - 113
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