A multimodal approach to assess the validity of atrophied T2-lesion volume as an MRI marker of disease progression in multiple sclerosis

Atrophied T2-lesion volume (LV) is a novel MRI marker representing brain-lesion loss due to atrophy, able to predict long-term disability progression and conversion to secondary-progressive multiple sclerosis (MS). To better characterize atrophied T2-LV via comparison with other multidisciplinary markers of MS progression. We studied 127 MS patients (85 relapsing–remitting, RRMS and 42 progressive, PMS) and 20 clinically isolated syndrome (CIS)...