Associations Between Microstructure, Amyloid, and Cognition in Amnestic Mild Cognitive Impairment and Dementia

Background:Although amyloid-β (Aβ) and microstructural brain changes are both effective biomarkers of Alzheimer’s disease, their independent or synergistic effects on cognitive decline are unclear. Objective:To examine associations of Aβ and brain microstructure with cognitive decline in amnestic m ild cognitive impairment and dementia. Methods:Restriction spectrum imaging, cerebrospinal fluid Aβ, and longitudinal cognitive data were collected...