Candidate Causal Variants at the 8p12 Breast Cancer Risk Locus Regulate DUSP4
Abstract
Genome-wide association studies have revealed a locus at 8p12 that is associated with breast cancer risk. Fine-mapping of this locus identified 16 candidate causal variants (CCVs). However, as these variants are intergenic, their function is unclear. To map chromatin looping from this risk locus to a previously identified candidate target gene, DUSP4, we performed chromatin conformation capture analyses in normal and tumoural breast cell lines....
Paper Details
Title
Candidate Causal Variants at the 8p12 Breast Cancer Risk Locus Regulate DUSP4
Published Date
Jan 10, 2020
Journal
Volume
12
Issue
1
Pages
170 - 170
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