Multi-antigen-targeted chimeric antigen receptor T cells for cancer therapy
Abstract
The approval of two chimeric antigen receptor-modified T cell types by the US Food and Drug Administration (FDA) for the treatment of hematologic malignancies is a milestone in immunotherapy; however, the application of CAR-T cells has been limited by antigen escape and on-target, off-tumor toxicities. Therefore, it may be a potentially effective strategy to select appropriate targets and to combine multi-antigen-targeted CAR-T cells with "OR",...
Paper Details
Title
Multi-antigen-targeted chimeric antigen receptor T cells for cancer therapy
Published Date
Nov 29, 2019
Volume
12
Issue
1
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