Comparison of the thoracic CT-based computational model with hyperpolarized Xenon-129 MRI and SPECT images to assess pulmonary ventilation in COPD patients

Introduction: Thoracic computed tomography (CT) is a clinically established diagnostic technique to detect structural pulmonary abnormalities but provides no functional pulmonary information. Objectives: The current study aims to demonstrate the use of the CT-based full-scale airway network (FAN) flow model to assess ventilation in COPD patients and to compare the modelling results obtained with hyperpolarized Xenon-129 (HPX)...