Brain-to-cervical lymph node signaling after stroke
Abstract
After stroke, peripheral immune cells are activated and these systemic responses may amplify brain damage, but how the injured brain sends out signals to trigger systemic inflammation remains unclear. Here we show that a brain-to-cervical lymph node (CLN) pathway is involved. In rats subjected to focal cerebral ischemia, lymphatic endothelial cells proliferate and macrophages are rapidly activated in CLNs within 24 h, in part via VEGF-C/VEGFR3...
Paper Details
Title
Brain-to-cervical lymph node signaling after stroke
Published Date
Nov 22, 2019
Journal
Volume
10
Issue
1
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