Identification of novel CDK2 inhibitors by a multistage virtual screening method based on SVM, pharmacophore and docking model

Volume: 35, Issue: 1, Pages: 235 - 244
Published: Nov 25, 2019
Abstract
Cyclin-dependent kinase 2 (CDK2) is the family of Ser/Thr protein kinases that has emerged as a highly selective with low toxic cancer therapy target. A multistage virtual screening method combined by SVM, protein-ligand interaction fingerprints (PLIF) pharmacophore and docking was utilised for screening the CDK2 inhibitors. The evaluation of the validation set indicated that this method can be used to screen large chemical databases because it...
Paper Details
Title
Identification of novel CDK2 inhibitors by a multistage virtual screening method based on SVM, pharmacophore and docking model
Published Date
Nov 25, 2019
Volume
35
Issue
1
Pages
235 - 244
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