Wnt regulates amino acid transporter Slc7a5 and so constrains the integrated stress response in mouse embryos

Amino acids are essential for cellular metabolism, and it is important to understand how nutrient supply is coordinated with changing energy requirements during embryogenesis. Here, we show that the amino acid transporter Slc7a5 / Lat1 is highly expressed in tissues undergoing morphogenesis and that Slc7a5 ‐null mouse embryos have profound neural and limb bud outgrowth defects. Slc7a5 ‐null neural tissue exhibited aberrant mTORC1 activity and...