Inhibition of melanin production and promotion of collagen production by the extract of Kuji amber.

Published on Mar 3, 2020in Bioscience, Biotechnology, and Biochemistry2.043
· DOI :10.1080/09168451.2019.1693251
Satoshi Suzuki1
Estimated H-index: 1
,
Junpei Abe2
Estimated H-index: 2
(Iwate University)
+ 2 AuthorsKen-ichi Kimura27
Estimated H-index: 27
(Iwate University)
Sources
Abstract
ABSTRACTKuji amber is fossilized tree resin of the Late Cretaceous in Japan. In this study, new biological activities of ethanol extract of Kuji amber (EtOH ext.) and supercritical carbon dioxide f...
References26
Newest
For the discovery of novel drug candidates and bioprobes, it is important to investigate rare natural sources with unique screening methods. Our group tested 1000 original MeOH extracts from natural sources, such as plants and food ingredients using six types of mutant yeasts. In our experiments, Kuji amber was used as the rare domestic natural source and the growth-restoring activity (positive screening) of mutant yeast involving Ca2+-signal transduction was used as a unique screening method. A...
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#1Honoka Takahashi (Iwate University)H-Index: 3
#2Hiroyuki KoshinoH-Index: 58
Last. Ken-ichi Kimura (Iwate University)H-Index: 27
view all 5 authors...
ABSTRACTA novel labdane type diterpenoid, 15-nor-8-labden-13-ol, named kujigamberol C, was isolated from Kuji amber using a modified isolation method to increase the yield of biologically active co...
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#1Eisaku Shimizu (Iwate University)H-Index: 3
#2Hiroyuki KoshinoH-Index: 58
Last. Ken-ichi Kimura (Iwate University)H-Index: 27
view all 8 authors...
Abstract A different type of biologically active compound from Kuji amber (Late Cretaceous, Japan) before the K-Pg boundary [65 million years ago (Ma)] was isolated based on the growth-restoring activity of a mutant yeast involving Ca2+ signal transduction. It was identified as a spirolactone norditerpenoid, (4R*, 5S*, 8R*, 9R*, 10S*)-14,15,16,19-tetranor-labdan-13,9-olide (1) from spectral analyses with high-resolution electron ionization mass spectrometry (HREIMS), 1D and 2D nuclear magnetic r...
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#1Honoka Takahashi (Iwate University)H-Index: 3
#2Nozomu Shimoda (Iwate University)H-Index: 2
Last. Ken-ichi Kimura (Iwate University)H-Index: 27
view all 4 authors...
ABSTRACTThe aldehyde and carboxylic acid derivatives of kujigamberol were synthesized using pyridinium dichromate (PDC). The carboxylic acid derivative exhibited lower cytotoxicity and inhibited the degranulation of rat basophilic leukemia-2H3 (RBL-2H3) cells stimulated by thapsigargin more than kujigamberol. The carboxylic acid derivative was detected and isolated from the methanol extract of Kuji amber (MEKA) by the modified isolation procedure. Thus, it has been named as kujigamberoic acid A.
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#1Christoph S. Nabzdyk (Harvard University)H-Index: 15
#2Edward A. Bittner (Harvard University)H-Index: 35
: Ascorbic acid (vitamin C) elicits pleiotropic effects in the body. Among its functions, it serves as a potent anti-oxidant, a co-factor in collagen and catecholamine synthesis, and a modulator of immune cell biology. Furthermore, an increasing body of evidence suggests that high-dose vitamin C administration improves hemodynamics, end-organ function, and may improve survival in critically ill patients. This article reviews studies that evaluate vitamin C in pre-clinical models and clinical tri...
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Introduction: Silanol (organic silicon) has been used for decades in the treatment of skin photoaging as it stabilizes and maintains skin structures through hydrogen bonding electrostatic interaction with extracellular matrix (ECM) proteins or glycosaminoglycans. Organic silicon-based products are often presented as silanol derivatives which are currently associated to other structural molecules such as orthohydroxybenzoate, carboxymethyl theophylline alginate, ascorbate, acetyltyrosine, sodium ...
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ABSTRACTAurea Helianthus (AH), also known as wild confederate rose or golden sunflower, is a curative herb. It has been used as a medicinal material in China due to its anti-inflammatory, immune regulatory, and anti-oxidant activities. However, its melanogenic effect on skin has not been sufficiently investigated. In this study, we tested whether AH has melanogenic inhibitory activities for the development of effective skin whitening agent. The extract showed inhibition of melanin synthesis and ...
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#1Sayuri Fukuhara (Kyoto Institute of Technology)H-Index: 4
#2Riho Tanigaki (Kyoto Institute of Technology)H-Index: 2
Last. Takao Kataoka (Kyoto Institute of Technology)H-Index: 34
view all 4 authors...
Abstract Kujigamberol is the norlabdane compound isolated from Kuji amber and has recently been shown to prevent Ca2+-signal transduction and exert anti-allergy effects in vitro and in vivo. However, the anti-inflammatory activities of kujigamberol remain unclear. In the present study, we investigated the biological activities of kujigamberol on cell adhesion molecules expressed on human umbilical vein endothelial cells (HUVEC) in response to pro-inflammatory cytokines. Kujigamberol decreased th...
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#1Tobias Mann (Beiersdorf)H-Index: 7
#2Wolfram Gerwat (Beiersdorf)H-Index: 5
Last. Ludger Kolbe (Beiersdorf)H-Index: 21
view all 10 authors...
Tyrosinase is the rate-limiting enzyme of melanin production and, accordingly, is the most prominent target for inhibiting hyperpigmentation. Numerous tyrosinase inhibitors have been identified, but most of those lack clinical efficacy because they were identified using mushroom tyrosinase as the target. Therefore, we used recombinant human tyrosinase to screen a library of 50,000 compounds and compared the active screening hits with well-known whitening ingredients. Hydroquinone and its derivat...
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#1Miku Maruyama (Iwate University)H-Index: 4
#2Miki Kobayashi (Iwate University)H-Index: 3
Last. Ken-ichi Kimura (Iwate University)H-Index: 27
view all 8 authors...
Abstract Amber is fossilized tree resin and several biologically active compounds were isolated from ambers using the growth-restoring activity of the mutant yeast [Saccharomyces cerevisiae (zds1∆ erg3∆ pdr1∆ pdr3∆)] involving Ca2+-signal transduction. The aim of this study is to investigate the anti-allergic effect of both the methanol extract of Kuji amber (MEKA) and its main biologically active constituent, kujigamberol (15,20-dinor-5,7,9-labdatrien-18-ol) having activity against the mutant y...
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Amber is a type of fossil tree resin with several bioactive properties and has been traced in traditional medicines used in Russia and China. However, its anti-inflammatory activities are poorly characterized. Here, the anti-inflammatory effects of the extract of amber mined from Kaliningrad, Russia was investigated in lipopolysaccharide (LPS)-induced RAW 264.7 cells. The effect of the amber extract on cell viability was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide ...
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Abstract null null Alzheimer disease (AD) is an irreversible, progressive brain disease. Amyloid β plays a critical role in AD development. Some Chinese traditional medicines, such as the fossilized plant resin, amber, have been applied as mental stabilizers. However, the effects of amber on AD pathogenesis remain unknown. Therefore, we aimed to determine the potential of amber extract for treating AD by evaluating its effects on amyloid-β (1-42) (Aβ (1-42))-induced neuronal cell death. We measu...
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