Autonomic nerve dysfunction and impaired diabetic wound healing: The role of neuropeptides.

Published on Jan 1, 2020in Autonomic Neuroscience: Basic and Clinical2.2
· DOI :10.1016/J.AUTNEU.2019.102610
Georgios Theocharidis6
Estimated H-index: 6
(BIDMC: Beth Israel Deaconess Medical Center),
Aristidis Veves76
Estimated H-index: 76
(BIDMC: Beth Israel Deaconess Medical Center)
Abstract Lower extremity ulcerations represent a major complication in diabetes mellitus and involve multiple physiological factors that lead to impairment of wound healing. Neuropeptides are neuromodulators implicated in various processes including diabetic wound healing. Diabetes causes autonomic and small sensory nerve fibers neuropathy as well as inflammatory dysregulation, which manifest with decreased neuropeptide expression and a disproportion in pro- and anti- inflammatory cytokine response. Therefore to fully understand the contribution of autonomic nerve dysfunction in diabetic wound healing it is crucial to explore the implication of neuropeptides. Here, we will discuss recent studies elucidating the role of specific neuropeptides in wound healing.
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The work was funded by the Danish Council for Independent Research, Technology and Production, grant 4005‐00029; Strategic Project POCI‐01‐0145‐FEDER‐007440 funded by FEDER through Operational Programme Competitiveness Factors, the European Foundation for the Study of Diabetes (Novartis European Research Programme in Microvascular Complications of Diabetes), and FCT; and Pepper grant P30 AG028718 and NIGMS‐NIH P20GM109096 to EC.
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