The role of heparin/heparan sulphate in the IFN-γ-led Arena
Abstract
IFN-γ (Interferon-gamma) is a pleiotropic cytokine. It is often involved in a variety of physiological processes by binding to the cell surface transmembrane receptor (IFN-γR) to initiate a series of signalling pathways that transmit external signals from cell surface receptors to the cell nucleus. Heparan sulphate (HS), a highly sulphated linear polysaccharide, is ubiquitous on the mammalian cell surface and extracellular matrix. Electrostatic...
Paper Details
Title
The role of heparin/heparan sulphate in the IFN-γ-led Arena
Published Date
Mar 1, 2020
Journal
Volume
170
Pages
1 - 9
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History