Sustained-release of PDGF from PLGA microsphere embedded thermo-sensitive hydrogel promoting wound healing by inhibiting autophagy

Growth factors (GFs) act as important active molecules for the treatment of skin wounds. However, their clinical translation is seriously restrained due to single function and short half-life. Besides, the underlying GFs-mediated wound healing mechanism remains elusive. Therefore, we aimed to develop a thermo-sensitive chitosan hydrogel embedding with poly lactic-co-glycolic acid (PLGA) microspheres which can deliver platelet-derived growth...