Mitochondrial Toxicogenomics for Antiretroviral Management: HIV Post-exposure Prophylaxis in Uninfected Patients

Background: Mitochondrial genome has been used in multiple fields as research, diagnosis and toxicogenomics. Several compounds damage mitochondrial DNA (mtDNA), including biological and therapeutic agents, as the human immunodeficiency virus (HIV) and its concomitant antiretroviral treatment. HIV-infected and treated patients may show impaired mitochondrial and metabolic profile. However, specific contribution of treatment or viral toxicity into...