MMP9 modulates the metastatic cascade and immune landscape for breast cancer anti-metastatic therapy
Abstract
Metastasis, the main cause of cancer-related death, has traditionally been viewed as a late-occurring process during cancer progression. Using the MMTV-PyMT luminal B breast cancer model, we demonstrate that the lung metastatic niche is established early during tumorigenesis. We found that matrix metalloproteinase 9 (MMP9) is an important component of the metastatic niche early in tumorigenesis and promotes circulating tumor cells to colonize...
Paper Details
Title
MMP9 modulates the metastatic cascade and immune landscape for breast cancer anti-metastatic therapy
Published Date
Nov 14, 2019
Journal
Volume
2
Issue
6
Pages
e201800226 - e201800226
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