Modifiable lifestyle risk factors and C-reactive protein in patients with coronary artery disease: Implications for an anti-inflammatory treatment target population.

Published on Apr 10, 2021in European Journal of Preventive Cardiology5.864
· DOI :10.1177/2047487319885458
Christopher Blaum3
Estimated H-index: 3
,
Fabian J Brunner8
Estimated H-index: 8
+ 12 AuthorsChristoph Waldeyer12
Estimated H-index: 12
Sources
Abstract
BackgroundModifiable lifestyle risk factors (modRF) of coronary artery disease (CAD) are associated with increased inflammation represented by elevated C-reactive protein (CRP) levels. Lifestyle ch...
📖 Papers frequently viewed together
90 Citations
64 Citations
52 Citations
References45
Newest
#1Karl Stattin (Uppsala University)H-Index: 5
#2Lars Lind (Uppsala University)H-Index: 134
Last. Liisa Byberg (Uppsala University)H-Index: 46
view all 8 authors...
AimsWe aimed to discover and replicate associations between leisure-time physical activity and cardiovascular candidate plasma protein biomarkers and to examine whether the associations were indepe...
8 CitationsSource
#1Kornelia Kotseva (European Society of Cardiology)H-Index: 35
#2Guy De Backer (UGent: Ghent University)H-Index: 75
Last. Euroaspire InvestigatorsH-Index: 5
view all 45 authors...
AimsThe aim of this study was to determine whether the Joint European Societies guidelines on secondary cardiovascular prevention are followed in everyday practice.DesignA cross-sectional ESC-EORP ...
242 CitationsSource
Last. Milagros Rocha (University of Valencia)H-Index: 35
view all 9 authors...
The relationship between caloric restriction-mediated weight loss and the generation of ROS and its effects on atherosclerotic markers in obesity is not fully understood. Therefore, we set out to investigate whether dietary weight loss intervention improves markers of oxidative stress in leukocytes and subclinical parameters of atherosclerosis. This was an interventional study of 59 obese subjects (BMI > 35 kg/m2) who underwent 6 months of dietary therapy, including a 6-week very-low-calorie die...
9 CitationsSource
#1Christoph WaldeyerH-Index: 12
#2Fabian J BrunnerH-Index: 8
Last. Renate B. Schnabel (CAU: University of Kiel)H-Index: 32
view all 18 authors...
Abstract Background and aims Guidelines recommend a healthy diet as a cornerstone of cardiovascular disease (CVD) prevention. Although the Mediterranean diet (MD) is the best studied dietary pattern for CV outcomes, data on association between MD and severity of CAD are limited. Therefore, we analysed dietary data in association with the SYNTAX score in coronary artery disease (CAD) patients from the INTERCATH study. Methods The INTERCATH study is an observational study in patients undergoing co...
14 CitationsSource
#1John Munkhaugen (University of Oslo)H-Index: 9
#2Jan Erik OtterstadH-Index: 19
Last. Lars Gullestad (University of Oslo)H-Index: 79
view all 7 authors...
ObjectiveAn interleukin-beta antagonist reduces the risk of subsequent cardiovascular events in coronary patients with high-sensitivity C-reactive protein (hs-CRP) ≥2 mg/L. It remains to be defined how large the coronary population at inflammatory risk is, and what the predictors of elevated risk are.MethodsA cross-sectional study investigated the proportion of patients with elevated hs-CRP (i.e. ≥2 mg/L) and the respective demographic and clinical predictors in 971 patients without concomitant ...
19 CitationsSource
#1Carlos Lahoz (ISCIII: Carlos III Health Institute)H-Index: 42
#2Elisa CastilloH-Index: 2
Last. Carmen GarcésH-Index: 19
view all 15 authors...
Background: Adherence to a Mediterranean diet seems to be inversely associated with C-reactive protein (CRP) concentration. A 14-point Mediterranean Diet Adherence Screener (MEDAS) has been developed to assess dietary compliance. Objective: The aim of this study was to assess whether each of the MEDAS questions as well as their final score were associated with the levels of CRP in general Spanish population. Methods: Cross-sectional analysis of 1411 subjects (mean age 61 years, 43.0% males) rand...
18 CitationsSource
#1Christoph WaldeyerH-Index: 12
#2Moritz SeiffertH-Index: 27
Last. Renate B. Schnabel (CAU: University of Kiel)H-Index: 32
view all 16 authors...
Abstract Purpose Although the efficacy of lipid-lowering medication (LLM) in patients with coronary artery disease (CAD) is well established, the majority of patients fail to achieve their LDL-C goals. The evidence for measurement of LDL-C to achieve these goals is limited. The goal of the present study, therefore, was to analyze ambulatory LLM management in relation to performance of LDL-C measurements and achieved LDL-C levels after the initial diagnosis of CAD. Methods The study followed up a...
5 CitationsSource
#1Paul M. Ridker (Brigham and Women's Hospital)H-Index: 252
#2Brendan M. Everett (Novartis)H-Index: 41
Last. Robert J. GlynnH-Index: 168
view all 28 authors...
BackgroundExperimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. MethodsWe conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The ...
3,479 CitationsSource
#1Michael V. Fedewa (UA: University of Alabama)H-Index: 12
#2Elizabeth D. Hathaway (UGA: University of Georgia)H-Index: 6
Last. Christie L. Ward-Ritacco (URI: University of Rhode Island)H-Index: 6
view all 3 authors...
Purpose C-reactive protein (CRP) is a marker of chronic systemic inflammation frequently used in cardiovascular disease risk assessment. The purpose of this meta-analysis was to provide a quantitative estimate of the magnitude of change in CRP following participation in physical exercise interventions. Methods All studies included in the meta-analysis were peer reviewed and published in English. Human participants were assigned to a non-exercise comparison group or exercise training group, with ...
109 CitationsSource
Abstract Background and aims Modern tobacco regulatory science requires an understanding of which biomarkers of cardiovascular injury are most sensitive to cigarette smoking exposure. Methods We studied self-reported current smokers from the Multi-Ethnic Study of Atherosclerosis. Smoking intensity was defined by number of cigarettes/day and urinary cotinine levels. Subclinical cardiovascular injury was assessed using markers of inflammation [high-sensitivity C-reactive protein (hsCRP), interleuk...
46 CitationsSource
Cited By15
Newest
#1Christopher BlaumH-Index: 3
#2Fabian J BrunnerH-Index: 8
Last. Peter ClemmensenH-Index: 63
view all 14 authors...
ABSTRACT null null Purpose null The lowered LDL-C treatment goal of the 2019 European Society of Cardiology dyslipidemia guidelines results in a significant increase in the projected need for cost-intensive proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors. Addition of bempedoic acid (BA) to established oral lipid-lowering medication (LLM) has the potential to enable affordable LDL-C goal attainment, particularly in patients with statin intolerance (SI). The goal of this study was...
Source
#1Yankun Wang (IU: Indiana University)
#2Rodrigo X. Armijos (IU: Indiana University)H-Index: 20
Last. Mary Margaret Weigel (IU: Indiana University)
view all 4 authors...
Low-grade systemic inflammation is implicated in metabolic syndrome (MetS) and cardiometabolic diseases. Diet is hypothesized to be an important low-grade inflammation modifier. However, few studies have examined the association of dietary inflammation with MetS and cardiometabolic risk in Latin American populations and their findings are inconsistent. Our cross-sectional study examined the association of dietary inflammatory potential with MetS and cardiometabolic risk components in 276 urban E...
Source
#1Isabella Zanella (University of Brescia)H-Index: 16
#2Giorgio Biasiotto (University of Brescia)H-Index: 26
Last. Eugenia Quiros-Roldan (University of Brescia)H-Index: 29
view all 8 authors...
Persistent inflammation, despite anti-retroviral therapy (ART), is an independent predictor of mortality and comorbidities in HIV infection. Multiple factors, including lifestyle and chronic viral coinfections, may contribute. Several of these factors are also associated with a chronic inflammation in the general population. Little is known about the degree to which these factors influence inflammation in HIV infection, particularly within the first year of ART. The purpose of this study was to ...
Source
#1Charulata Jindal (University of Newcastle)H-Index: 6
#2Ashesh N. Buch (ECU: East Carolina University)H-Index: 18
Last. Jimmy T. Efird (Duke University)H-Index: 54
view all 3 authors...
Source
#1Geza Halasz (University of Parma)H-Index: 2
#2Massimo F Piepoli (University of Parma)H-Index: 9
Source
#1Fábio Trindade (University of Porto)H-Index: 11
#2Luís Perpétuo (University of Aveiro)
Last. Rui Vitorino (University of Aveiro)H-Index: 39
view all 7 authors...
The increasing prevalence of periodontal and cardiovascular diseases is the result of a sedentary lifestyle associated with poor diet, obesity, hypercholesterolemia, smoking habits, alcohol consumption and stress. The present study aims to uncover molecular associations between periodontitis and coronary heart disease using an unbiased strategy of automatic text mining traditionally applied to bibliometric studies. A total of 1,590 articles on these diseases were retrieved from the Web of knowle...
1 CitationsSource
BACKGROUND The recently updated European Society of Cardiology (ESC) dyslipidaemia guidelines recommend a lower low-density lipoprotein cholesterol (LDL-C) goal of <55 mg/dL for patients with atherosclerotic cardiovascular disease (ASCVD), with a concomitant Class IA upgrade for proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) for patients not reaching their LDL-C goal under conventional lipid-lowering therapy. AIMS We aim to quantify the need for PCSK9i and the related costs to...
4 CitationsSource
#1Natalie Arnold (UHH: University of Hamburg)H-Index: 1
#2Katharina Lechner (TUM: Technische Universität München)H-Index: 4
Last. Wolfgang Koenig (University of Ulm)H-Index: 129
view all 5 authors...
2 CitationsSource
#1María Lourdes Ladehesa-Pineda (UCO: University of Córdoba (Spain))
#2Iván Arias de la Rosa (UCO: University of Córdoba (Spain))H-Index: 7
Last. Eduardo Collantes-Estevez (UCO: University of Córdoba (Spain))H-Index: 31
view all 13 authors...
Aims:To evaluate the association of estimated cardiovascular (CV) risk and subclinical atherosclerosis with radiographic structural damage in patients with axial spondyloarthritis (axSpA).Methods:C...
2 CitationsSource
#1Yan Liu (JNU: Jinan University)H-Index: 2
Last. Jun Guo (JNU: Jinan University)H-Index: 2
view all 8 authors...
α1-antitrypsin (AAT) is a protein released as part of the anti-inflammatory response. It regulates the activity of serine proteinases and has a crucial role in the pathogenesis of acute coronary syndrome (ACS). The present study aimed to examine its role in patients with ACS. The plasma samples of 117 patients were collected at the Cardiology Department of the Affiliated Hospital of Youjiang Medical University (Baise, China). These included 46 cases of ACS (who met the diagnostic criteria for AC...
Source