RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2
Abstract
Sex determination of the gonads begins with fate specification of gonadal supporting cells into either ovarian pre-granulosa cells or testicular Sertoli cells. This fate specification hinges on a balance of transcriptional control. Here we report that expression of the transcription factor RUNX1 is enriched in the fetal ovary in rainbow trout, turtle, mouse, goat, and human. In the mouse, RUNX1 marks the supporting cell lineage and becomes...
Paper Details
Title
RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2
Published Date
Nov 11, 2019
Journal
Volume
10
Issue
1
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