Cell Surface GRP78 as a Death Receptor and an Anticancer Drug Target
Abstract
Cell surface GRP78 (csGRP78, glucose-regulated protein 78 kDa) is preferentially overexpressed in aggressive, metastatic, and chemo-resistant cancers. GRP78 is best studied as a chaperone protein in the lumen of endoplasmic reticulum (ER), facilitating folding and secretion of the newly synthesized proteins and regulating protein degradation as an ER stress sensor in the unfolded protein pathway. As a cell surface signal receptor, multiple...
Paper Details
Title
Cell Surface GRP78 as a Death Receptor and an Anticancer Drug Target
Published Date
Nov 13, 2019
Journal
Volume
11
Issue
11
Pages
1787 - 1787
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