Relationship between pattern electroretinogram and optic disc morphology in glaucoma.

Published on Nov 7, 2019in PLOS ONE3.24
路 DOI :10.1371/JOURNAL.PONE.0220992
Soo Ji Jeon8
Estimated H-index: 8
(Catholic University of Korea),
Hae-Young Lopilly Park30
Estimated H-index: 30
(Catholic University of Korea)
+ 1 AuthorsChan Kee Park28
Estimated H-index: 28
(Catholic University of Korea)
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Abstract
Purpose To evaluate the relationship between pattern electroretinogram (PERG) and optic disc morphology in glaucoma suspect and glaucoma.
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#1Michael Bach (University of Freiburg)H-Index: 60
#2Anne-Kathrin CunoH-Index: 1
Last. Michael B. HoffmannH-Index: 26
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Abstract The pattern electroretinogram (PERG), an indicator of retinal ganglion cell (RGC) function, comprises a P50 and an N95 component. We addressed the question of whether the N95 originates, like the P50, from the RGC bodies or from the change of axon orientation at the optic nerve head (ONH). Thus, we recorded multifocal PERGs for 36 retinal locations in 21 participants. Second-order kernel responses were analyzed for the dependence of peak time topography on retinal fiber lengths to the O...
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#2Hae Young L Park (Catholic University of Korea)H-Index: 2
#3Yi Ryeung ParkH-Index: 1
It is generally acknowledged that structural loss can precede functional loss in some patients with early glaucoma. However, conventional standard automated perimetry (SAP) has limitations in the detection of functional loss, especially in the macular area. This study explores visual field loss in the macular areas of patients with preperimetric glaucoma exhibiting structural thinning in the area by examining the correlations between the ganglion cell-inner plexiform layer (GCIPL) and the result...
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#1Kyoung In Jung (Catholic University of Korea)H-Index: 13
#2Chan Kee Park (Catholic University of Korea)H-Index: 28
Purpose To evaluate an effective functional strategy for detecting glaucomatous damage of the macula in preperimetric to perimetric glaucoma. Design Cross-sectional study. Methods Preperimetric glaucoma patients (n聽=聽102) and perimetric glaucoma patients (n聽= 88) with isolated paracentral scotoma or combined paracentral scotoma were enrolled in this study. Global and sectoral mean sensitivities (MS) were evaluated using 10-2 standard automated perimetry (SAP) with a stimulus of sizes III (0.43-d...
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#1Barbara Cvenkel (Ljubljana University Medical Centre)H-Index: 13
#2Maja SustarH-Index: 10
Last. Darko Perov拧ek (Ljubljana University Medical Centre)H-Index: 4
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Purpose To evaluate discrimination ability of pattern electroretinography (PERG) and photopic negative response (PhNR) between early glaucoma and healthy controls, and their relationship with structural measurements using spectral-domain optical coherence tomography (SD-OCT).
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Purpose of reviewElectrophysiological measures of vision function have for decades generated interest among glaucoma researchers and clinicians alike because of their potential to help elucidate pathophysiological processes and sequence of glaucomatous damage, as well as to offer a potential complem
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#1Younhea Jung (Catholic University of Korea)H-Index: 10
#2Hae-Young Lopilly Park (Catholic University of Korea)H-Index: 30
Last. Chan Kee Park (Catholic University of Korea)H-Index: 28
view all 5 authors...
To better understand functional loss in the macular area of preperimetric glaucoma patients exhibiting structural loss by exploring correlations between parameters of the ganglion cell-inner plexiform layer (GCIPL) and 10-2 short-wavelength perimetry (SWAP).One hundred thirty-four patients underwent 10-2 SWAP and conventional 24-2 visual field (VF) testing using a Humphrey field analyzer and macular scanning via Cirrus optical coherence tomography (OCT). Correlations between GCIPL thickness (GCI...
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#1Harsha L. Rao (LVPEI: L V Prasad Eye Institute)H-Index: 31
#2Manideepak Januwada (LVPEI: L V Prasad Eye Institute)H-Index: 5
Last. Chandra S. GarudadriH-Index: 20
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To compare the structure-function relationship between ganglion cell-inner plexiform layer (GCIPL) thickness measurements using spectral-domain optical coherence tomography (SDOCT) and visual sensitivities measured using standard automated perimetry (SAP) and microperimetry (MP) at the macula in glaucoma.In a prospective study, 45 control eyes (29 subjects) and 60 glaucoma eyes (45 patients) underwent visual sensitivity estimation at the macula (central 10掳) by SAP and MP, and GCIPL thickness me...
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The function of retinal ganglion cells (RGCs) can be non-invasively assessed in experimental and genetic models of glaucoma by means of variants of the ERG technique that emphasize the activity of inner retina neurons. The best understood technique is the Pattern Electroretinogram (PERG) in response to contrast-reversing gratings or checkerboards, which selectively depends on the presence of functional RGCs. In glaucoma models, the PERG can be altered before histological loss of RGCs; PERG alter...
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#1Athanasios Vergados (Athens State University)H-Index: 2
#2Dimitrios Papaconstantinou (Athens State University)H-Index: 3
Last. Ilias Georgalas (Athens State University)H-Index: 24
view all 6 authors...
AbstractBackground: It is well-established that eyes with pseudoexfoliation syndrome (PXS) have higher intraocular pressure (IOP). Early diagnosis of preperimetric glaucoma will assist with better management of these patients. The aim of this study is to evaluate the optic nerve head (ONH) parameters and retinal nerve fiber layer (RNFL) thickness in subjects with bilateral PXS, bilateral pseudoexfoliative glaucoma (PXG) and normal, correlating these results with central corneal thickness (CCT). ...
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#1Verena Prokosch (WWU: University of M眉nster)H-Index: 11
#2Nicole Eter (WWU: University of M眉nster)H-Index: 29
Purpose To compare the significance of white-on-white standard automated perimetry (SAP), matrix frequency doubling technology (FDT), and flicker-defined form perimetry (FDF) for early detection of nerve fiber layer loss in early glaucoma patients.
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Cited By4
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#1Andrew Tirsi (Manhattan Eye, Ear and Throat Hospital)
#2Vasiliki Gliagias (Hofstra University)H-Index: 1
Last. Celso Tello (Manhattan Eye, Ear and Throat Hospital)H-Index: 42
view all 9 authors...
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#1Vincenzo ParisiH-Index: 47
#2Lucia ZiccardiH-Index: 17
Last. Francesco OddoneH-Index: 26
view all 8 authors...
Purpose: To evaluate the retinal ganglion cells (RCG) function and the neural conduction along the post-retinal large and small axons and its correlation with retinal nerve fiber layer thickness (RNFL-T) in open angle glaucoma (OAG) eyes. Methods: Thirty-seven OAG patients (mean age: 51.68卤9.83 years) with 24-2 Humphrey mean deviation (MD) between -2.5 and - 20 dB and IOP < 21 mmHg in pharmacological treatment (OAG Group) and 20 age-matched controls (Control Group) were enrolled. In both Groups,...
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In this study, we investigated the correlation between pattern electroretinogram (PERG) and optical coherence tomography angiography (OCTA) parameters for diagnosis in patients with normal-tension glaucoma (NTG). Forty-nine normal individuals (49 eyes) and 60 patients with NTG (60 eyes) were enrolled. OCTA and PERG parameters, such as macular vessel density (VD) and the amplitude of N35-P50 and P50-N95, were measured. Correlation analyses were performed between the parameters, and the area under...
Source
#1Denis GubinH-Index: 11
#2Vladimir NeroevH-Index: 1
Last. Dietmar Weinert (MLU: Martin Luther University of Halle-Wittenberg)H-Index: 12
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Glaucoma is a progressive optic neuropathy associated with damage to retinal ganglion cells (RGCs) and disrupted circadian rhythms. Melatonin is a promising substance to ameliorate glaucoma-associated compromised circadian rhythms, sleep, mood, and retinal cells function. However, studies estimating melatonin effects in glaucoma are currently lacking. Therefore, In this study, we investigated the effect of long-term (daily at 10:30 p.m. for 90 days) oral melatonin administration on systemic (Tb)...
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#1Taekjune Lee (Yonsei University)H-Index: 6
#2Du Ri Seo (Yonsei University)
Last. Hyoung Won Bae (Yonsei University)H-Index: 11
view all 9 authors...
Purpose: The pattern electroretinogram (PERG) is useful to detect retinal ganglion cell (RGC) damage in patients with glaucoma. Optical coherence tomography angiography (OCTA) measures retinal vessel density (VD), which is known to be reduced in glaucoma. There may be correlations between parameters of the PERG and OCTA in open-angle glaucoma (OAG). Methods: In total, 95 eyes of 95 OAG patients and 102 eyes of 102 normal controls were included in this study. N35, P50, and N95 latency along with ...
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