Microglial memory of early life stress and inflammation: Susceptibility to neurodegeneration in adulthood
Abstract
We review evidence supporting the role of early life programming in the susceptibility for adult neurodegenerative diseases while highlighting questions and proposing avenues for future research to advance our understanding of this fundamental process. The key elements of this phenomenon are chronic stress, neuroinflammation triggering microglial polarization, microglial memory and their connection to neurodegeneration. We review the mediating...
Paper Details
Title
Microglial memory of early life stress and inflammation: Susceptibility to neurodegeneration in adulthood
Published Date
Oct 1, 2020
Volume
117
Pages
232 - 242
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