Inhibition of SARS-CoV 3CL protease by flavonoids.

Published on Dec 1, 2020in Journal of Enzyme Inhibition and Medicinal Chemistry4.673
· DOI :10.1080/14756366.2019.1690480
Seri Jo4
Estimated H-index: 4
(Ewha Womans University),
Suwon Kim5
Estimated H-index: 5
(Ewha Womans University)
+ 1 AuthorsMi-Sun Kim5
Estimated H-index: 5
(Ewha Womans University)
Sources
Abstract
AbstractThere were severe panics caused by Severe Acute Respiratory Syndrome (SARS) and Middle-East Respiratory Syndrome-Coronavirus. Therefore, researches targeting these viruses have been require...
Figures & Tables
Download
📖 Papers frequently viewed together
970 Citations
2,407 Citations
254 Citations
References30
Newest
#1Mércia Marques Jucá (UFC: Federal University of Ceará)H-Index: 2
#2Francisco Mauricio Sales Cysne Filho (UFC: Federal University of Ceará)H-Index: 1
Last. Silvânia Maria Mendes Vasconcelos (UFC: Federal University of Ceará)H-Index: 34
view all 11 authors...
AbstractFlavonoids have aroused much interest in research, since they present a great diversity of biological activities observed in vitro, such as: antioxidant effect, modulation of the enzymatic ...
67 CitationsSource
#1Hovakim ZakaryanH-Index: 10
#2Erik ArabyanH-Index: 6
Last. Keivan Zandi (UM: University of Malaya)H-Index: 30
view all 4 authors...
Flavonoids are widely distributed as secondary metabolites produced by plants and play important roles in plant physiology, having a variety of potential biological benefits such as antioxidant, anti-inflammatory, anticancer, antibacterial, antifungal and antiviral activity. Different flavonoids have been investigated for their potential antiviral activities and several of them exhibited significant antiviral properties in in vitro and even in vivo studies. This review summarizes the evidence fo...
133 CitationsSource
#1Sandra Frabasile (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 8
#2Andrea Cristine Koishi (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 11
Last. Juliano Bordignon (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 19
view all 7 authors...
Dengue is one of the most significant health problems in tropical and sub-tropical regions throughout the world. Nearly 390 million cases are reported each year. Although a vaccine was recently approved in certain countries, an anti-dengue virus drug is still needed. Fruits and vegetables may be sources of compounds with medicinal properties, such as flavonoids. This study demonstrates the anti-dengue virus activity of the citrus flavanone naringenin, a class of flavonoid. Naringenin prevented i...
57 CitationsSource
#1Li-Yuan Yang (SJTU: Shanghai Jiao Tong University)H-Index: 2
#2Jun LinH-Index: 5
Last. Baoquan Zhu (SJTU: Shanghai Jiao Tong University)H-Index: 5
view all 5 authors...
AbstractThis study aimed to isolate active compounds from traditional Chinese medicinal Taxillus sutchuenensis to inhibit hepatitis C virus (HCV) NS3 protease activity. Under the guidance of bioassay, 10 compounds were isolated from the EtOAc extract fraction, which were identified as inhibitors of HCV NS3 protease. IC50 values of these compounds were obtained, and a broad degree of anti-HCV activity was observed. The most active compounds were kaempferol-3,7-bisrhamnoside (19.4 μM) and (3S)-3-h...
12 CitationsSource
#1Emmie de Wit (NIH: National Institutes of Health)H-Index: 53
#2Neeltje van Doremalen (NIH: National Institutes of Health)H-Index: 30
Last. Vincent J. Munster (NIH: National Institutes of Health)H-Index: 77
view all 4 authors...
Insights into coronavirus emergence, replication and pathogenesis gained from the SARS and MERS outbreaks have guided the development of preventive and therapeutic measures. In this Review, Munster and colleagues highlight recent achievements and areas that need to be addressed to combat novel coronaviruses.
1,819 CitationsSource
#1Andong Wu (WHU: Wuhan University)H-Index: 9
#2Yi Wang (WHU: Wuhan University)H-Index: 6
Last. Deyin Guo (WHU: Wuhan University)H-Index: 36
view all 9 authors...
Abstract Coronavirus 3C-like protease (3CLpro) is responsible for the cleavage of coronaviral polyprotein 1a/1ab (pp1a/1ab) to produce the mature non-structural proteins (nsps) of nsp4–16. The nsp5 of the newly emerging Middle East respiratory syndrome coronavirus (MERS-CoV) was identified as 3CLpro and its canonical cleavage sites (between nsps) were predicted based on sequence alignment, but the cleavability of these cleavage sites remains to be experimentally confirmed and putative non-canoni...
25 CitationsSource
Middle East respiratory syndrome coronavirus (MERS-CoV) is a highly pathogenic virus that causes severe respiratory illness accompanied by multi-organ dysfunction, resulting in a case fatality rate of approximately 40%. As found in other coronaviruses, the majority of the positive-stranded RNA MERS-CoV genome is translated into two polyproteins, one created by a ribosomal frameshift, that are cleaved at three sites by a papain-like protease and at 11 sites by a 3C-like protease (3CLpro). Since 3...
57 CitationsSource
#1Silvia SchwarzH-Index: 5
#2Daniel Sauter (Goethe University Frankfurt)H-Index: 10
Last. Wolfgang Schwarz (Goethe University Frankfurt)H-Index: 11
view all 9 authors...
The protein coded by the open-reading-frame 3a of SARS coronavirus has been demonstrated to form a cation-selective channel that may become expressed in the infected cell. The activity of the channel is involved in the mechanism of virus release. Drugs that inhibit the ion channel can, therefore, inhibit virus release, and they could be a source for development of novel therapeutic antiviral agents. Various drugs found in Chinese herbs that are well known as anticancer agents also have an antivi...
82 CitationsSource
#1Andy Kilianski (LUC: Loyola University Chicago)H-Index: 8
#2Anna M. Mielech (LUC: Loyola University Chicago)H-Index: 12
Last. Susan C. Baker (LUC: Loyola University Chicago)H-Index: 65
view all 4 authors...
ABSTRACT Middle East respiratory syndrome coronavirus (MERS-CoV) is associated with an outbreak of more than 90 cases of severe pneumonia with high mortality (greater than 50%). To date, there are no antiviral drugs or specific therapies to treat MERS-CoV. To rapidly identify potential inhibitors of MERS-CoV replication, we expressed the papain-like protease (PLpro) and the 3-chymotrypsin-like protease (3CLpro) from MERS-CoV and developed luciferase-based biosensors to monitor protease activity ...
104 CitationsSource
#1Zhilin Ren (THU: Tsinghua University)H-Index: 3
#2Liming Yan (NKU: Nankai University)H-Index: 1
Last. Zihe RaoH-Index: 76
view all 7 authors...
Emerging Infection Disease Program, High-throughput Molecular Drug Discovery Center, Tianjin Joint Academy of Biomedicine and Technology, Tianjin 300457, China Correspondence: raozh@xtal.tsinghua.edu.cnFrom the global outbreak of SARS-CoV caused infection disease in 2003, coronaviruses (CoVs) are known to be a great threat to the human health. Recently, a new SARS-like coronavirus, human betacoronavirus 2c EMC/2012 (HCoV-EMC), has been identified and the appearance of this new CoV raises concer...
97 CitationsSource
Cited By270
Newest
#1Linh Tran (Duy Tan University)H-Index: 8
Last. Nguyen Tien Huy (Nagasaki University)H-Index: 27
view all 5 authors...
Source
Reactivity investigation of N-(phenylsulfonyl)acetamide derivatives with nitrogen nucleophiles to give the corresponding aminothiazole, aminooxazole, 2H-benzo[b][1,4]oxazin-3-yl, 2H-benzo[b][1,4]thiazin-3-yl, quinoxalin-2-yl, pyridin-4-ylamino, benzo[d]thiazol-2-ylthio and 1Hbenzo[d]imidazol-2-ylthio derivatives;respectively null The sulphonamides were examined in vitro antimalarial activity and characterized their ADMET properties, with IC50 values of <30µ M null The synthesized sulfonamide had...
1 Citations
Currently, the entire globe is under the deadliest pandemic of Covid-19 caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). At present, no specific treatment is available to combat COVID-19 infection. Euphorbia hirta (Euphorbiaceae) have been reported for a variety of biological activities, including antiviral. The present investigation aimed to identify potential phytoconstituents of the plant E. hirta from the category flavonoids and coumarins against the SARS-CoV-2 using i...
Source
#1Mohamed S. AttiaH-Index: 22
Last. Noha I. ZiedanH-Index: 7
view all 5 authors...
The novel coronavirus pandemic (COVID-19) caused by SARS-CoV-2 has affected more than 53 million individuals worldwide. Currently, there is a dire need to develop or find potential drugs that can treat SARS-CoV-2 infection. One of the standard methods to accelerate drug discovery and development in pandemics is to screen currently available medications against the critical therapeutic targets to find potential therapeutic agents. The literature has pointed out the 3CLpro and RdRp proteins as the...
Source
#1Yumei Sun (HAU: Huazhong Agricultural University)H-Index: 2
#2Chang Li (HAU: Huazhong Agricultural University)H-Index: 2
Last. Qigai He (HAU: Huazhong Agricultural University)H-Index: 25
view all 8 authors...
Abstract null null Pseudorabies virus (PRV) accounts for a critical swine disease incurring economic losses worldwide. Several PRV vaccines are commercially available but these vaccines are effective against only certain prevalent PRV strains in China. To prevent PRV-induced latent infection and decrease the pathogenicity, novel anti-PRV drugs are required to prevent PRV infection. Natural products show exceptional structural diversity representing an important source for developing novel therap...
Source
#1Xiaohan Wei (Southern Medical University)
#2Zhejun Zhao (Southern Medical University)
Last. Xiaomei Tan (Southern Medical University)H-Index: 8
view all 4 authors...
Abstract null null Ethnopharmacological relevance null Herbacetin is an active constituent of traditional Chinese medicines such as Ephedra sinica Stapf (MaHuang) and Sedum roseum (L.). Scop. (Hong JingTian). MaHuang was used to treat cough, asthma, fever, and edema for more than 5000 years, while Hong JingTian was used to treat depression, fatigue, cancers, and cardiovascular disease. Recent studies indicate that herbacetin and its glycosides play a critical role in the pharmacological activiti...
Source
Source
#1Armiya Sultan (Jamia Millia Islamia)H-Index: 6
#2Rafat Ali (Jamia Millia Islamia)H-Index: 2
Last. Sher Ali (Sharda University)H-Index: 1
view all 4 authors...
The COVID-19 pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is a global health emergency warranting development and implementation of targeted treatment. The enzyme main protease (Mpro; also known as 3C-like protease) is emerging as an attractive drug target. This enzyme plays an indispensable role in processing the translated polyproteins of viral RNA. Inhibiting the activity of Mpro would wedge viral replication. To facilitate the discovery of targeted t...
Source
#1Laleh Babaeekhou (IAU: Islamic Azad University)H-Index: 4
#2Maryam Ghane (IAU: Islamic Azad University)H-Index: 3
Last. Mahdi Abbas-Mohammadi (University of Kashan)
view all 3 authors...
Since there is no general agreement on drug treatment of SARS-CoV-2, the search for a new drug capable of treating COVID-19 is of utmost priority. This study aims to dereplicate the chemical compounds of the methanol extract of Salvia officinalis and Artemisia dracunculus, and assay the inhibitory effect of these compounds as well as the previously dereplicated components of Zingiber officinale against SARS-CoV-2 in an in-silico study. A molecular networking (MN) technique was applied to find th...
Source
#1Ming Lyu (Tianjin University of Traditional Chinese Medicine)H-Index: 1
#2Guanwei Fan (Tianjin University of Traditional Chinese Medicine)H-Index: 23
Last. Han Zhang (Tianjin University of Traditional Chinese Medicine)H-Index: 6
view all 15 authors...
COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread across the globe, posing an enormous threat to public health and safety. Traditional Chinese medicine (TCM), in combination with Western medicine (WM), has made important and lasting contributions in the battle against COVID-19. In this review, updated clinical effects and potential mechanisms of TCM, presented in newly recognized three distinct phases of the disease, are summarized and discussed....
Source