Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches
Abstract
Tumor cells must generate sufficient ATP and biosynthetic precursors in order to maintain cell proliferation requirements. Otto Warburg showed that tumor cells uptake high amounts of glucose producing large volumes of lactate even in the presence of oxygen, this process is known as "Warburg effect or aerobic glycolysis." As a consequence of such amounts of lactate there is an acidification of the extracellular pH in tumor microenvironment,...
Paper Details
Title
Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches
Published Date
Nov 1, 2019
Journal
Volume
9
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Notes
History