Transcriptome-based molecular subtyping of non–small cell lung cancer may predict response to immune checkpoint inhibitors

Abstract

Objectives

We set out to investigate whether transcriptome-based molecular subtypes in lung adenocarcinoma and lung squamous cell carcinoma are predictive of the response to programmed cell death 1 blockade.

Methods

Molecular classification of non–small cell lung cancer was performed by unsupervised clustering of mRNA sequencing data from 87 lung adenocarcinoma and 101 lung squamous cell carcinoma specimens,...