The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature
Abstract
Endothelial cells actively maintain an anti-thrombotic environment; loss of this protective function may lead to thrombosis and systemic coagulopathy. The transcription factor ERG is essential to maintain endothelial homeostasis. Here, we show that inducible endothelial ERG deletion (ErgiEC-KO) in mice is associated with spontaneous thrombosis, hemorrhages and systemic coagulopathy. We find that ERG drives transcription of the anticoagulant...
Paper Details
Title
The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature
Published Date
Nov 1, 2019
Journal
Volume
10
Issue
1
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