The Vicious Cycle Between α‐Synuclein Aggregation and Autophagic‐Lysosomal Dysfunction

The accumulation and misfolding of α‐synuclein (α‐syn) represent the main pathological hallmark of PD. Overexpression of α‐syn and failure of cellular protein degradation systems play a major role in α‐syn aggregation. The discovery of PD‐associated genes related to the autophagic‐lysosomal pathway, such as VPS35 , LRRK2 , GBA1 , SMPD1 , GALC , ASAH1 , SCARB2 , CTSD , CTSB , and GLA , confirms the involvement of cellular clearance systems...