The α4β7 blockade with vedolizumab is effective in prevention of graft vs. host disease using a xenogeneic mouse model
Abstract
Acute graft vs host disease (aGVHD) leads to significant morbidity and mortality after allogeneic hematopoietic cell transplant (allo-HCT). A critical step during GVHD development involves donor T-cells migrating to Peyer's patches, leading to generation of host-reactive cytotoxic T lymphocytes, (Peyer's patch is the essential gut site in initiating murine acute and lethal graft-vs-host reaction). Conditioning regimen-related tissue damage leads...
Paper Details
Title
The α4β7 blockade with vedolizumab is effective in prevention of graft vs. host disease using a xenogeneic mouse model
Published Date
Dec 11, 2019
Volume
95
Issue
2
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