Pathology

Virus

Mycobacterium tuberculosis

Tuberculosis vaccines

Tuberculosis

Monoclonal antibody

Biology

Antibody

Virology

Vaccination

Immunology

Adjuvant

Immunogen

Influenza vaccine

Medicine

Nature reviews. Immunology

Novel approaches to vaccine development include structure-based immunogen design, gene-based vaccine platforms and formulation of recombinant antigens with potent adjuvants. These technologies are producing encouraging results in the development of vaccines for globally important diseases such as tuberculosis, influenza and respiratory syncytial virus. Here we highlight the most important developments in these areas over the past 18 months. New approaches to vaccine development have generated exciting results over the past 18 months. Focusing on respiratory syncytial virus infection, influenza and tuberculosis, Fauci and Mascola discuss the impact of structure-based vaccine design, gene-based vaccine platforms and advances in adjuvant development.

Novel vaccine technologies for the 21st century