Isovitexin-Mediated Regulation of Microglial Polarization in Lipopolysaccharide-Induced Neuroinflammation via Activation of the CaMKKβ/AMPK-PGC-1α Signaling Axis

Microglia, proinflammatory M1 and anti-inflammatory M2 phenotypes immune cells in the brain, has the function of phagocytosis of foreign bodies in the central nervous system. Overactivated microglia causes the production of a large number of neurotoxic factors, which cause neuroinflammatory response and then result in brain disorders. Inflammatory response in the brain plays a crucial part in the pathophysiology of many psychiatric and...