Development and Characterization of a Wee1 Kinase Degrader
Abstract
The G1/S cell cycle checkpoint is frequently dysregulated in cancer, leaving cancer cells reliant on a functional G2/M checkpoint to prevent excessive DNA damage. Wee1 regulates the G2/M checkpoint by phosphorylating CDK1 at Tyr15 to prevent mitotic entry. Previous drug development efforts targeting Wee1 resulted in the clinical-grade inhibitor, AZD1775. However, AZD1775 is burdened by dose-limiting adverse events, and has off-target PLK1...
Paper Details
Title
Development and Characterization of a Wee1 Kinase Degrader
Published Date
Jan 1, 2020
Journal
Volume
27
Issue
1
Pages
57 - 65.e9
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