Loss of ZnT8 function protects against diabetes by enhanced insulin secretion

Volume: 51, Issue: 11, Pages: 1596 - 1606
Published: Nov 1, 2019
Abstract
A rare loss-of-function allele p.Arg138* in SLC30A8 encoding the zinc transporter 8 (ZnT8), which is enriched in Western Finland, protects against type 2 diabetes (T2D). We recruited relatives of the identified carriers and showed that protection was associated with better insulin secretion due to enhanced glucose responsiveness and proinsulin conversion, particularly when compared with individuals matched for the genotype of a common T2D-risk...
Paper Details
Title
Loss of ZnT8 function protects against diabetes by enhanced insulin secretion
Published Date
Nov 1, 2019
Volume
51
Issue
11
Pages
1596 - 1606
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