The YB-1:Notch-3 axis modulates immune cell responses and organ damage in systemic lupus erythematosus
Abstract
Systemic lupus erythematosus (SLE) is an autoimmune disease and lupus nephritis is a major risk factor for morbidity and mortality. Notch-3 signaling induced by membrane-bound or soluble ligands such as YB-1 constitutes an evolutionarily conserved pathway that determines major decisions in cell fate. Mass spectrometry of extracellular YB-1 in sera from patients with SLE and lupus-prone mice revealed specific post-translational guanidinylation of...
Paper Details
Title
The YB-1:Notch-3 axis modulates immune cell responses and organ damage in systemic lupus erythematosus
Published Date
Feb 1, 2020
Journal
Volume
97
Issue
2
Pages
289 - 303
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