Brainstem serotonergic, catecholaminergic, and inflammatory adaptations during chronic hypercapnia in goats

Despite the prevalence of CO 2 retention in human disease, little is known about the adaptive neurobiological effects of chronic hypercapnia. We have recently shown 30‐d exposure to increased inspired CO 2 (InCO 2 ) leads to a steady‐state ventilation that exceeds the level predicted by the sustained acidosis and the acute CO 2 /H + chemoreflex, suggesting plasticity within respiratory control centers. Based on data showing brainstem changes in...