MA25.07 Genomic Profiling of Lung Adenocarcinoma by Targeted NGS Using Extracellular Vesicle-Derived DNA in Bronchoalveolar Lavage Fluid

Extracellular vesicles (EV) are membrane-bound and nanometer-sized particles shed from most types of cells in our body and found in circulation, containing double-stranded genomic DNA reflecting mutational status of the parental tumor cells. Recently, we demonstrated that EVs successfully isolated from bronchoalveolar lavage fluid (BALF) in non-small cell lung cancer (NSCLC) patients. Several studies also have shown that EV-derived DNA is...