P1.01-32 Bronchoalveolar Lavage as an Alternative to Rebiopsy for Detection of T790M Mutation in NSCLC Patients with Acquired Resistance to EGFR-TKIs

Rebiopsy is current standard to detect T790M mutation but has limited value due to inaccessibility in significant number of patients. Plasma liquid biopsy using ctDNA has been adopted, but the sensitivity is not satisfactory. Extracellular vesicles (EVs) have been proven to contain double-stranded genomic DNA reflecting mutational status of the parental tumor cells in non-small cell lung cancer (NSCLC). Accordingly, EVs can be translated into...