Investigation of mathematical models based on diffusion control release for Paclitaxel from in-situ forming PLGA microspheres containing HSA microparticles

Paclitaxel-loaded poly(lactic acid-co-glycolic acid) (PLGA) microspheres containing different portions of human serum albumin microparticles (mHSA) were prepared via an in situ forming method. The low solubility of Paclitaxel and presence of an external oil phase around the in situ-formed microspheres were investigated with the mathematical models based on the diffusion-control release. The release data were fitted with diffusion-based...