Causal effects of serum metabolites on amyotrophic lateral sclerosis: A Mendelian randomization study.

Published on Mar 8, 2020in Progress in Neuro-psychopharmacology & Biological Psychiatry4.361
· DOI :10.1016/J.PNPBP.2019.109771
Lihong Yang1
Estimated H-index: 1
(Xi'an Jiaotong University),
Xiaohong Lv6
Estimated H-index: 6
(Xi'an Jiaotong University)
+ 2 AuthorsMengchang Wang1
Estimated H-index: 1
(Xi'an Jiaotong University)
Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that is affected by both genetic and environmental factors. Nowadays, OMIC technologies, such as genomics and metabolomics, are providing a systematic readout of genetic structures and physiological states for understanding human diseases. However, the comprehensive analysis of cross-omics is often lacking. Here, we conducted a Mendelian randomization analysis to provide a comprehensive analysis of metabolomics and genomics to estimate the causal relationships between non-targeted human serum metabolites and the development of ALS. Using genetic variants as predictors, our study detected 18 metabolites that might have causal effects on the development of ALS, including a group of gamma-glutamyl amino acids. Our findings suggested that glutathione metabolism dysfunction might be involved in the pathogenesis of ALS. Furthermore, our study provides a novel method to understand the pathogenesis of human diseases and develop therapeutic strategies for diseases by combining metabolomics with genomics.
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