Gene Expression Profiles in Primary Sjögren's Syndrome With and Without Systemic Manifestations

Objective To investigate the gene expression profile in patients with Sjögren's syndrome that is characterized by different clinical phenotypes. Methods RNA from peripheral blood mononuclear cells was purified in 8 patients with glandular features ( GF s) and widespread pain ( WP ) and 11 with extraglandular manifestations ( EGM s) and then was analyzed by hybridization on a human gene chip exploring more than 40,000 human genes. Differentially...