Structural Mechanisms of PTEN Regulation
Volume: 10, Issue: 3, Pages: a036152 - a036152
Published: Oct 21, 2019
Abstract
The tumor suppressor phosphatase and tensin homolog on chromosome 10 (PTEN) is a tightly regulated enzyme responsible for dephosphorylating the progrowth lipid messenger molecule phosphatidylinositol 3,4,5-trisphosphate (PIP3) on the plasma membrane. The carboxy-terminal tail (CTT) of PTEN is key for regulation of the enzyme. When phosphorylated, the unstructured CTT interacts with the phosphatase-C2 superdomain to inactivate the enzyme by...
Paper Details
Title
Structural Mechanisms of PTEN Regulation
Published Date
Oct 21, 2019
Volume
10
Issue
3
Pages
a036152 - a036152
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