IgG Fc glycosylation as an axis of humoral immunity in childhood

In children, antibody levels and repertoire diversity mature with age. A further determinant of humoral immunocompetence, still poorly characterized in the pediatric population, is IgG Fc glycosylation. Paired biantennary glycans at asparagine 297 in each heavy chain modulate the ability of IgG to bind complement, Fcγ receptors, and other ligands. The availability of more than 30 glycoforms provides the opportunity to “fine-tune” IgG effector...