High-Throughput Mass Spectrometry Assay for Quantifying β-Amyloid 40 and 42 in Cerebrospinal Fluid

Volume: 65, Issue: 12, Pages: 1572 - 1580
Published: Dec 1, 2019
Abstract
BACKGROUND The ratio of β-amyloid 1–42 (Aβ42) to Aβ40 in cerebrospinal fluid (CSF) may be useful for evaluating Alzheimer disease (AD), but quantification is limited by factors including preanalytical analyte loss. We developed an LC-MS/MS assay that limits analyte loss. Here we describe the analytical characteristics of the assay and its performance in differentiating patients with AD from non-AD dementia and healthy controls. METHODS To...
Paper Details
Title
High-Throughput Mass Spectrometry Assay for Quantifying β-Amyloid 40 and 42 in Cerebrospinal Fluid
Published Date
Dec 1, 2019
Volume
65
Issue
12
Pages
1572 - 1580
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