TEM8/ANTXR1-specific CAR T cells mediate toxicity in vivo

Volume: 14, Issue: 10, Pages: e0224015 - e0224015
Published: Oct 17, 2019
Abstract
Engineering T-cells to express receptors specific for antigens present on tumour tissue is proving a highly effective treatment for some leukaemias. However, extending this to solid tumours requires antigens that can be safely and effectively targeted. TEM8, a marker overexpressed on the vasculature of some solid tumours, has been proposed as one such target. A recent report stated that T-cells engineered to express a TEM8-specific chimeric...
Paper Details
Title
TEM8/ANTXR1-specific CAR T cells mediate toxicity in vivo
Published Date
Oct 17, 2019
Journal
Volume
14
Issue
10
Pages
e0224015 - e0224015
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