P4-363: IMPROVING ACCURACY OF MCI DIAGNOSIS AND PROGNOSIS: A COGNITIVE-GENETIC APPROACH

Diagnostic accuracy of mild cognitive impairment (MCI) is important for prognosis, i.e., identifying individuals at risk of progression to Alzheimer's disease (AD). We previously divided ADNI MCI cases into those who were or were not also impaired on a second test—the Rey Auditory Verbal Learning Test (AVLT). The 3-year rate of progression to AD was dramatically different in the AVLT- and AVLT+ subgroups (51% vs 16%, p<.001), and CSF Aβ and tau...