AKT signaling promotes DNA damage accumulation and proliferation in polycystic kidney disease

Published: Oct 18, 2019
Abstract
Polycystic kidney disease (PKD) results in the formation of renal cysts that can impair function leading to renal failure. DNA damage accumulates in renal epithelial cells in PKD but the molecular mechanisms are unclear and are investigated here. Phosphoinositide 3- kinase (PI3K)/AKT signaling activates mammalian target of rapamycin complex 1 (mTORC1) and hyperactivation of mTORC1 is a common event in PKD, however, mTORC1 inhibitors have yielded...
Paper Details
Title
AKT signaling promotes DNA damage accumulation and proliferation in polycystic kidney disease
Published Date
Oct 18, 2019
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