Impact of obeticholic acid on the lipoprotein profile in patients with non-alcoholic steatohepatitis

•OCA has shown promise as a potential treatment of non-alcoholic steatohepatitis.•OCA is associated with increased LDL-cholesterol, triglycerides, total cholesterol and reduced HDL-cholesterol.•After 12 weeks of OCA therapy, atherogenic and less atherogenic lipoprotein levels increased.•The increase in lipoproteins during OCA therapy was reversed following the discontinuation of treatment.•OCA therapy also led to a reduction in large- and...