Integrated metabolomics and network toxicology to reveal molecular mechanism of celastrol induced cardiotoxicity

Volume: 383, Pages: 114785 - 114785
Published: Nov 1, 2019
Abstract
Celastrol (CS), an active triterpene derived from traditional Chinese medicine Tripterygium wilfordii Hook. f, has been used to treat chronic inflammation, arthritis and other diseases. However, it has been reported that CS can trigger cardiotoxicity and the molecular mechanism of heart injury induced by CS is not clear. Considering the wide application of Tripterygium wilfordii Hook. f in clinics, it is necessary to develop an accurate and...
Paper Details
Title
Integrated metabolomics and network toxicology to reveal molecular mechanism of celastrol induced cardiotoxicity
Published Date
Nov 1, 2019
Volume
383
Pages
114785 - 114785
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