Exquisite sensitivity of adrenocortical carcinomas to induction of ferroptosis

Significance The currently used treatment regimen for the cancers of the adrenal cortex involves mitotane, a nonspecific derivative of the pesticide DDT (1,1-(dichlorobiphenyl)-2,2-dichloroethane), which has an unclear mechanism of action. Our studies in cell culture and genetic analysis of public databases demonstrate that human adrenocortical carcinomas (ACCs) are remarkably sensitive to a recently defined cell death pathway referred to as...