P4-046: A NORMATIVE MODELING BASED ANALYSIS OF AMYLOID, COGNITION, AND TAU IN PRECLINICAL ALZHEIMER'S DISEASE

Analysis of associations between various risk factors of Alzheimer's disease (AD) during the preclinical stages is essential in understanding early disease processes. However, the statistical signals in these biomarkers are often heterogeneous. In this study, we propose the normative modeling to capture the relationship between various biomarkers in preclinical AD (amyloid, tau, and cognitive trajectories) where clinical patterns are...