P1-414: ASSOCIATION OF BRAIN MICROSTRUCTURE AND AMYLOID-β WITH COGNITIVE DECLINE IN EARLY ALZHEIMER'S DISEASE

Amyloid-β accumulates in early stages of Alzheimer's disease (AD) and is thought to contribute to neurodegenerative processes leading to cognitive impairment. Microstructural compromise to gray and white matter, measurable with diffusion imaging, correlates with cognitive decline in AD, though the role of amyloid in the microstructural events contributing to cognitive impairment is uncertain. We used the advanced diffusion MRI technique...