P1-550: REFINING A LATENT DEMENTIA INDICATOR FOR A MULTI-STUDY CONSORTIUM

A variety of dementia indicators have been proposed in lieu of clinical diagnoses, ranging from cutoff scores on a cognitive screening measure such as MMSE to weighted combinations of cognitive test scores. Latent variable dementia indicators, “delta” (δ), are reliable predictors of dementia risk (Gavett et al., Peh et al., Royall & Palmer). δ reflects variance in a set of cognitive and functional ability indicators beyond variance already...